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SOLU-KNEX® cleavable linker features a Val-Cit dipeptide
Product Name DOTA-tris(t-Bu)ester-PEG2 Synonyms CAS Number n/a Related CAS Molecular Formula C32H61N5O9 Molecular Weight 659
707 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCCCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
32 SMILES COCC(=O)N[C@@H](CC1=CC=C(C=C1)C1=CC(Cl)=CC(Cl)=C1)[C@H](O)[C@@H](O)C(C)=O Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO
By fusing eDHFR to a protein of interest and introducing TMP linked to a probe—such as a fluorescent dye
CRBN5-SNAP2-0C-PIP Size:100nmol SOLU-KNEX® cleavable linker features aCRBN5 SNAP2 0C PIP is a SNAP PROteolysis TArgeting Chimera (SNAP PROTAC), which recruit the VHL or CRBN ubiquitin E3 ligases to induce the degradation of SNAP fusion proteins. Endogenous tagging enabled the visualization and the selective depletion of a SNAP clathrin light chain fusion protein using SNAP PROTACs. The addition of PROTACs to the SNAP tag reagent toolbox facilitates the comprehensive analysis of protein function with a single gene
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