Mal-Propionyl-PEG2-Val-Ala-PAB(m-PEG8)-PNP m-peg8-pab Product Name DOTA-heptyne Synonyms CAS

Product Name DOTA-heptyne Synonyms CAS Number n/a Related CAS Molecular Formula C23H39N5O7 Molecular Weight 497

With a peak absorption at 584 nm

Product Name DOTA-tris(t-Bu)ester-C4-propanamido-maleimide Synonyms CAS Number Related CAS Molecular Formula C39H67N7O10 Molecular Weight 794

Cell Reports 2021

61 SMILES [2H]C([2H])([2H])NC1=C(Cl)C=C(F)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-PEG2-Val-Ala-PAB(m-PEG8)-PNP m-peg8-pab Product Name DOTA-heptyne Synonyms CASSOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating