Similarly, if the Mayor is blocked by a 2/2 with first strike, he will die before your other 2 humans get to deal damage in the second damage step, where they will just be 2/2s again
For the occasional removal of artifacts or enchantments, I will give preference to an Acidic Slime over a Nature's Claim
This, partnered with the Sabrina Trainer card, will have the player questioning their next move
Platinum Angel was probably the next card on the list, and it argued that it prevented you from losing the game, but I still say better luck on the next ballot
They need a higher density of threats or ways to refill in order to keep up with the early interruption
While its technically possible to give a player poison counters directly (Caress of Phyrexia comes to mind), the most popular poison counters strategy involves running a bunch of infect or toxic creatures